Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. As a result, SARMs result in anabolic cellular activity while avoiding most of the side effects of available today steroid drugs. SARMs have been studied from the treatment of cancer of the breast and cachexia and possess recently been utilized as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.

Aim
To provide the backdrop, mechanisms, current and potential clinical applications, along with risks and advantages of SARMs.

Methods
A literature review was performed in MEDLINE with all the terms selective androgen receptor modulator, hypogonadism, cachexia, cancers of the breast, benign prostatic hyperplasia, libido, and lean body mass. Both basic research and clinical tests were included.

Main Outcome Measure
To perform a review of peer-reviewed literature.

Results
Nevertheless, there are presently no U.S. Drug and food Agency-approved indications for SARMs, investigators are checking out the potential uses for these compounds. Basic research has dedicated to the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability having a paucity of drug interactions. Early clinical tests have demonstrated potential ways to use SARMs in the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good success.

Conclusion
SARMs have several possible clinical applications, with promise for your safe use in treating cachexia, BPH, hypogonadism, cancers of the breast, and prostate type of cancer.

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