SINCE Wwii, medical science has progressed to some stage where competitive medications are around to treat the identical ailment in different people. This is not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall consider the various factors that decide picking a a particular drug.

Safety: The next sub-criteria must be considered beneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug even when it’s certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the potential side-effect of addiction.

* Long-term safety: drug directory may be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and many chemicals react to create a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually generate the same influence on the identical organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two prescription medication is more serious.

Tolerability: A drug may be effective and not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability have to be looked at. Efficacy: A drug is not equally good at all patients. For example, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of who don’t, who therefore have to be prescribed another anti-depressant. The speed of oncoming of therapeutic action is a vital factor to be looked at too.

Cost: Cost does not always mean the price tag on acquiring some medicine alone. It must also cover the price tag on management of a complication that may arise while using another drug. Example: In the person who insists on taking alcohol but has to be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (including tricyclics) could cause a new problem in such patients, which may need a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.

Simplicity of treatment: The best mode of administration is preferred. If you have an option between an injection and oral administration, aforementioned is preferred when the efficacy of the two modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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