SINCE World war 2, medical science has progressed with a stage where competitive medications are for sale to treat the identical ailment in several people. This isn’t nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall consider the various factors that decide picking a a particular drug.

Safety: The next sub-criteria has to be considered under the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug even though it has certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but come with the possibility side-effect of addiction.

* Long-term safety: medication might be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals answer develop a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects on a single or maybe more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by due to the metabolism. This causes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually create the same effect on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both drugs are more serious.

Tolerability: A medication might be effective but not tolerable by all patients. Example: Allergies to a particular drugs in some people. Short-term and long-term tolerability must be taken into account. Efficacy: A medication just isn’t equally good at all patients. For instance, some patients with depression or panic attacks experience relief from escitalopram, but there are several that do not, who therefore must be prescribed some other anti-depressant. The rate of start of therapeutic action is a crucial step to be regarded too.

Cost: Cost doesn’t imply the price of purchase of a specific medicine alone. It ought to also cover the price of treatment of a complication that may arise from using some other drug. Example: Inside a individual who insists on taking alcohol and yet must be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (including tricyclics) could cause a whole new condition in such patients, which may require a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.

Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between a shot and oral administration, rogues is preferred if the efficacy of both modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to determine simplicity of treatment.
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