SINCE The second world war, medical science has progressed with a stage where competitive medications are available to treat exactly the same ailment in several people. This is simply not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall go through the various factors that decide your selection of a selected drug.

Safety: The next sub-criteria has to be considered beneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug regardless of whether it has certain side-effects as long as the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the possible side-effect of addiction.

* Long-term safety: drug directory could be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals respond to produce a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other, have certain effects on one or more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This will cause a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually make the same relation to exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two medicine is more serious.

Tolerability: A medicine could be effective and not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A medicine is not equally efficient at all patients. By way of example, some patients with depression or panic attacks experience rest from escitalopram, but there are many that do not, who therefore need to be prescribed a different anti-depressant. The pace of start of therapeutic action is a vital step to be considered too.

Cost: Cost does not always mean the cost of buying a particular medicine alone. It ought to also cover the cost of treating a complication that may arise by using a different drug. Example: In a person who insists on taking alcohol nevertheless has to be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (like tricyclics) can cause a fresh problem in such patients, which may demand a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in this patients.

Simple treatment: The easiest mode of administration is preferred. When there is an option between an injection and oral administration, the latter is preferred when the efficacy of the two modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to make a decision simplicity of treatment.
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