SINCE World War II, medical science has progressed to some stage where competitive medications are around to treat precisely the same ailment in several people. This is not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall glance at the various factors that decide selecting a certain drug.

Safety: These sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug regardless of whether they have certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possibility side-effect of addiction.

* Long-term safety: medication could be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals reply to make a different chemical, that have an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other person, have certain effects one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This will cause an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually produce the same effect on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the two prescription medication is more intense.

Tolerability: A drug could be effective but not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability should be considered. Efficacy: A drug just isn’t equally great at all patients. For example, some patients with depression or panic attacks experience rest from escitalopram, but there are many that don’t, who therefore should be prescribed a different anti-depressant. The rate of oncoming of therapeutic action is an important the answer to be considered too.

Cost: Cost does not mean the expense of purchase of a particular medicine alone. It ought to also cover the expense of treating a complication that could arise by using a different drug. Example: Within a individual that insists on taking alcohol but should be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (including tricyclics) could cause a fresh condition in such patients, which could demand a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.

Simple treatment: Most effective mode of administration is preferred. If there is a choice between an injection and oral administration, aforementioned is preferred when the efficacy of the two modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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